Shigeoka, Toshiaki; Koppers, Max; Wong, Hovy Ho Wai; Lin, Julie Qiaojin; Cagnetta, Roberta; Dwivedy, Asha; de Freitas Nascimento, Janaina; van Tartwijk, Francesca W.; Ströhl, Florian; Cioni, Jean Michel; Schaeffer, Julia; Carrington, Mark; Kaminski, Clemens F.; Jung, Hosung; Harris, William A.; Holt, Christine E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-10)
Ribosome assembly occurs mainly in the nucleolus,
yet recent studies have revealed robust enrichment
and translation of mRNAs encoding many ribosomal
proteins (RPs) in axons, far away from neuronal cell
bodies. Here, we report a physical and functional
interaction between locally synthesized RPs and ribosomes in the axon. We show that axonal RP translation is regulated through a sequence motif, ...